Showing posts with label health issues. Show all posts
Showing posts with label health issues. Show all posts
Wednesday, July 25, 2018
University Study Public Release - 'Good cholesterol' may not always be good"
PUBLIC RELEASE: 19-JUL-2018
'Good cholesterol' may not always be good
UNIVERSITY OF PITTSBURGH SCHOOLS OF THE HEALTH SCIENCES
PITTSBURGH, July 19, 2018 - Postmenopausal factors may have an impact on the heart-protective qualities of high-density lipoproteins (HDL) - also known as 'good cholesterol' - according to a study led by researchers in the University of Pittsburgh Graduate School of Public Health.
The findings, published today in Arteriosclerosis, Thrombosis, and Vascular Biology, a journal of the American Heart Association (AHA), indicate that this specific type of blood cholesterol may not translate into a lowered risk of cardiovascular disease in older women--bringing into question the current use of HDL cholesterol in a common equation designed to predict heart disease risk, particularly for women.
HDL is a family of particles found in the blood that vary in sizes and cholesterol contents. HDL has traditionally been measured as the total cholesterol carried by the HDL particles, known as HDL cholesterol. HDL cholesterol, however, does not necessarily reflect the overall concentration, the uneven distribution, or the content and function of HDL particles. Previous research has demonstrated the heart-protective features of HDL. This good cholesterol carries fats away from the heart, reducing the build-up of plaque and lowering the potential for cardiovascular disease.
"The results of our study are particularly interesting to both the public and clinicians because total HDL cholesterol is still used to predict cardiovascular disease risk," said lead author Samar R. El Khoudary, Ph.D., M.P.H., F.A.H.A., associate professor in Pitt Public Health's Department of Epidemiology. "This study confirms our previous work on a different group of women and suggests that clinicians need to take a closer look at the type of HDL in middle-aged and older women, because higher HDL cholesterol may not always be as protective in postmenopausal women as we once thought. High total HDL cholesterol in postmenopausal women could mask a significant heart disease risk that we still need to understand."
El Khoudary's team looked at 1,138 women aged 45 through 84 enrolled across the U.S. in the Multi-Ethnic Study of Atherosclerosis (MESA), a medical research study sponsored by the National Heart, Lung and Blood Institute of the National Institutes of Health (NIH). MESA began in 1999 and is still following participants today.
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Tuesday, July 17, 2018
Health News: Synthetic cancer indicator: An artificial mole as an early warning system
ScienceDaily
Date:
April 18, 2018
Source:
ETH Zurich
Summary:
Researchers have developed an early warning system for the four most common types of cancer. Should a tumor develop, a visible mole will appear on the skin.
Alongside cardiovascular disease, cancer has become the top cause of death in industrialised countries. Many of those affected are diagnosed only after the tumour has developed extensively. This often reduces the chance of recovery significantly: the cure rate for prostate cancer is 32 percent and only 11 percent for colon cancer. The ability to detect such tumours reliably and early would not only save lives, but also reduce the need for expensive, stressful treatment.
Researchers working with Martin Fussenegger, Professor at the Department of Biosystems Science and Engineering at ETH Zurich in Basel, have now presented a possible solution for this problem: a synthetic gene network that serves as an early warning system. It recognises the four most common types of cancer -- prostate, lung, colon and breast cancer -- at a very early stage, namely when the level of calcium in the blood is elevated due to the developing tumour.
The early warning system comprises a genetic network that biotechnologists integrate into human body cells, which in turn are inserted into an implant. This encapsulated gene network is then implanted under the skin where it constantly monitors the blood calcium level.
As soon as the calcium level exceeds a particular threshold value over a longer period of time, a signal cascade is triggered that initiates production of the body's tanning pigment melanin in the genetically modified cells. The skin then forms a brown mole that is visible to the naked eye.
The mole appears long before the cancer becomes detectable through conventional diagnosis. "An implant carrier should then see a doctor for further evaluation after the mole appears," explains Fussenegger. It is no reason to panic. "The mole does not mean that the person is likely to die soon," stresses the ETH professor. It simply means that clarification and if necessary treatment are needed.
The researchers used calcium as the indicator of the development of the four types of cancer, as it is regulated strongly in the body. Bones serve as a buffer that can balance out concentration differences. However, when too much calcium is detected in the blood, this may serve as a sign for one of the four cancers.
"Early detection increases the chance of survival significantly," says Fussenegger. For example, if breast cancer is detected early, the chance of recovery is 98 percent; however, if the tumour is diagnosed too late, only one in four women has a good chance of recovery. "Nowadays, people generally go to the doctor only when the tumour begins to cause problems. Unfortunately, by that point it is often too late."
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Wednesday, July 11, 2018
New Research Results! Reversing cognitive impairments in mice with dementia
Date:
June 8, 2018
Source:
Temple University Health System
Summary:
Reversing memory deficits and impairments in spatial learning is a major goal in dementia research. A lack of knowledge about cellular pathways critical to the development of dementia has prevented significant clinical advance. Researchers are breaking through that barrier. They show, for the first time in an animal model, that a drug can reverse tau pathology -- the second-most important lesion in the brain in patients with Alzheimer's.
The following report is from Science Daily
Reversing memory deficits and impairments in spatial learning is a major goal in the field of dementia research. A lack of knowledge about cellular pathways critical to the development of dementia, however, has stood in the way of significant clinical advance. But now, researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) are breaking through that barrier. They show, for the first time in an animal model, that tau pathology -- the second-most important lesion in the brain in patients with Alzheimer's disease -- can be reversed by a drug.
"We show that we can intervene after disease is established and pharmacologically rescue mice that have tau-induced memory deficits," explained senior investigator Domenico Praticò, MD, Scott Richards North Star Foundation Chair for Alzheimer's Research, Professor in the Departments of Pharmacology and Microbiology, and Director of the Alzheimer's Center at Temple at LKSOM. The study, published online in the journal Molecular Neurobiology, raises new hope for human patients affected by dementia.
The researchers landed on their breakthrough after discovering that inflammatory molecules known as leukotrienes are deregulated in Alzheimer's disease and related dementias. In experiments in animals, they found that the leukotriene pathway plays an especially important role in the later stages of disease.
"At the onset of dementia, leukotrienes attempt to protect nerve cells, but over the long term, they cause damage," Dr. Praticò said. "Having discovered this, we wanted to know whether blocking leukotrienes could reverse the damage, whether we could do something to fix memory and learning impairments in mice having already abundant tau pathology."
To recapitulate the clinical situation of dementia in humans, in which patients are already symptomatic by the time they are diagnosed, Dr. Praticò and colleagues used specially engineered tau transgenic mice, which develop tau pathology -- characterized by neurofibrillary tangles, disrupted synapses (the junctions between neurons that allow them to communicate with one another), and declines in memory and learning ability -- as they age. When the animals were 12 months old, the equivalent of age 60 in humans, they were treated with zileuton, a drug that inhibits leukotriene formation by blocking the 5-lipoxygenase enzyme.
After 16 weeks of treatment, animals were administered maze tests to assess their working memory and their spatial learning memory. Compared with untreated animals, tau mice that had received zileuton performed significantly better on the tests. Their superior performance suggested a successful reversal of memory deficiency.
Wednesday, June 27, 2018
World Health Organization: Top Issues Women's Health

Top Issues Women's Health
I found the following information on the World Health Organization
Dr. Flavia Bustreo, Assistant Director General for Family, Women’s and Children’s Health through the Life-course, World Health Organization
We've come a long way since 1995--and it is time to celebrate women and their achievements. But it is also time to take stock of how women’s rights are fulfilled in the world --especially the right to health. Twenty years after countries signed pledges in the 1995 Beijing Declaration and Platform of Action, women still face many health problems and we must re-commit to addressing them.
Issues regarding women's health that keep me awake at night:
Cancer: Two of the most common cancers affecting women are breast and cervical cancers. Detecting both these cancers early is key to keeping women alive and healthy. The latest global figures show that around half a million women die from cervical cancer and half a million from breast cancer each year. The vast majority of these deaths occur in low and middle income countries where screening, prevention and treatment are almost non-existent, and where vaccination against human papilloma virus needs to take hold.
In 2015, in too many countries, “women’s empowerment” remains a pipedream - little more than a rhetorical flourish added to a politician’s speech...
Dr Flavia Bustreo, ADG
HIV: Three decades into the AIDS epidemic, it is young women who bear the brunt of new HIV infections. Too many young women still struggle to protect themselves against sexual transmission of HIV and to get the treatment they require. This also leaves them particularly vulnerable to tuberculosis - one of the leading causes of death in low-income countries of women 20–59 years.
Sexually transmitted infections: I’ve already mentioned the importance of protecting against HIV and human papillomavirus (HPV) infection (the world’s most common STI). But it is also vital to do a better job of preventing and treating diseases like gonorrhoea, chlamydia and syphilis. Untreated syphilis is responsible for more than 200,000 stillbirths and early foetal deaths every year, and for the deaths of over 90 000 newborns.
Violence against women: Women can be subject to a range of different forms of violence, but physical and sexual violence – either by a partner or someone else – is particularly invidious. Today, one in three women under 50 has experienced physical and/or sexual violence by a partner, or non-partner sexual violence – violence which affects their physical and mental health in the short and long-term. It’s important for health workers to be alert to violence so they can help prevent it, as well as provide support to people who experience it.
Mental health: Evidence suggests that women are more prone than men to experience anxiety, depression, and somatic complaints – physical symptoms that cannot be explained medically. Depression is the most common mental health problem for women and suicide a leading cause of death for women under 60. Helping sensitise women to mental health issues, and giving them the confidence to seek assistance, is vital.
Noncommunicable diseases: In 2012, some 4.7 million women died from noncommunicable diseases before they reached the age of 70 —most of them in low- and middle-income countries. They died as a result of road traffic accidents, harmful use of tobacco, abuse of alcohol, drugs and substances, and obesity -- more than 50% of women are overweight in Europe and the Americas. Helping girls and women adopt healthy lifestyles early on is key to a long and healthy life.
Getting older: Having often worked in the home, older women may have fewer pensions and benefits, less access to health care and social services than their male counterparts. Combine the greater risk of poverty with other conditions of old age, like dementia, and older women also have a higher risk of abuse and generally, poor health.
When I lie awake thinking of women and their health globally, I remind myself: the world has made a lot of progress in recent years. We know more, and we are getting better at applying our knowledge. At providing young girls a good start in life.
And there has been an upsurge in high-level political will – evidenced most recently in the United Nations Secretary-General’s Global Strategy for Women’s and Children’s Health. Use of services, especially those for sexual and reproductive health, has increased in some countries. Two important factors that influence women’s health – namely, school enrolment rates for girls and greater political participation of women - have risen in many parts of the world.
But we are not there yet. In 2015, in too many countries, “women’s empowerment” remains a pipedream - little more than a rhetorical flourish added to a politician’s speech. Too many women are still missing out on the opportunity to get educated, support themselves, and obtain the health services they need, when they need them.
That’s why WHO is working so hard to strengthen health systems and ensure that countries have robust financing systems and sufficient numbers of well-trained, motivated health workers. That’s why WHO, with UN and world partners, are coming together at the UN Commission on Status of Women from 9-20 March 2015 in New York. We will look again at pledges made in the 1995 Beijing Declaration and Platform of Action with a view to renewing the global effort to remove the inequalities that put decent health services beyond so many women’s reach.
And that is why WHO and its partners are developing a new global strategy for women’s, children’s and adolescents’ health, and working to enshrine the health of women in the post 2015 United Nations’ Sustainable Development Goals. This means not only setting targets and indicators, but catalysing commitments in terms of policy, financing and action, to ensure that the future will bring health to all women and girls – whoever they are, wherever they live.
Wednesday, March 1, 2017
Not a diet. Healthy Eating.
I will be turning 60 this year and know that I need to make changes.
This past year I found out I had a small hiatal hernia: (Hiatal hernia occurs when a small part of your stomach slides up into your chest through a weak spot, or hiatus, in your diaphragm. A symptomatic hiatal hernia regurgitates stomach acid back into your esophagus, causing the heartburn, difficulty swallowing and chest pain associated with gastroesophageal reflux disease, or GERD. To manage a hiatal hernia, Cleveland Clinic advises you to maintain a healthy weight, stop smoking, eat small meals at least three hours to four hours before lying down and avoid fatty and acidic foods. Consult your doctor for advice and fill your plate with healthy foods to help alleviate symptoms.)
One thing I have done is add a probiotic every day. I have digestive issues that I never had before and it has made a big difference.
Looking at food recommendations, if you have any digestive issues, you may want to take a look.
On livestrong.com : Vegetables and Fruits
Vegetables are a great choice for side dishes and snacks as most won't aggravate a hiatal hernia. Dark leafy greens, such as broccoli and spinach, provide plenty of calcium and vitamin B, while red bell peppers and carrots are great sources of antioxidants. Other vegetables you can enjoy include kale, sweet potatoes, squash and string beans. Fruits containing antioxidants may help reduce or prevent symptoms from occurring, according to the University of Maryland Medical Center. Healthy fruits include apricots, cherries, raspberries, blueberries and cantaloupe. Avoid acidic and citrus fruits, such as tomatoes, grapefruit and oranges, because they can aggravate your heartburn.
Choose whole grains over refined starches to add fiber to your diet. Brown rice, steel-cut oatmeal, quinoa, whole-grain pasta and rye bread are smart whole-grain fiber choices. Avoid processed foods containing refined starches and sugar, such as commercially packaged cookies, cakes, crackers and white bread. Refined starches are also loaded with trans fatty acids; choose healthy fats, such as olive oil and safflower oil, instead. Keep your dairy choices low-fat because high-fat products may aggravate your hiatal hernia. Choose low-fat and no-fat milk, cottage cheese, sour cream and yogurt to add dairy to your diet.
Beverages
Water is the best beverage choice if you have a hiatal hernia. Avoid fruit juices, coffee and caffeinated beverages because they may cause hiatal hernia symptoms to appear. Alcohol and carbonated sodas may also cause problems. Herbal teas are fine, but stay away from peppermint tea because it may cause heartburn.
Precautions
Most hiatal hernias aren't problematic, but if you do experience symptoms, consult your physician. Medications, by prescription and over-the-counter, can alleviate the symptoms of hiatal hernia, but take them only under your doctor's supervision. Speak to your health care provider or dietitian before making any changes to your diet if you are pregnant or have a serious medical condition, such as diabetes or heart disease.
*Making these changes isn't that hard and is worth it!
*I am not a medical professional. Please consult your doctor before making any changes in diet and exercise.
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